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Sisters follows the lives and loves of four close, but very different, sisters of the Reed family living in Winnetka, Illinois. Alex, the oldest, is a wealthy, slightly snobish, WASP wife of a plastic surgeron. Teddy, is a free-spirited, artist/drifter seeking to find her place in life. Georgie, is a typical suburban housewife trying to keep the family together. Frankie, the youngest, is an overacheiving, businesswoman trying to make it big in the world.